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Figure 1 Fluorescent microscopy (100x) revealed marked enhancement of VEGF uptake with US and PESDA. A) reveals minimal endothelial uptake of VEGF after intravenous injection of VEGF without ultrasound. B) reveals minimal fluorescence in the endothelium after injection of buffer solution without VEGF. C) reveals significant deposition of VEGF in the endothelial cells with PESDA and US, using a Langendorff preparation. D) reveals significant deposition of VEGF in the endothelial cells with PESDA and US, after intravenous injection in short-term in vivo experiments. E) reveals significant deposition of VEGF in the endothelial cells with US alone, using a Langendorff preparation. F) reveals significant deposition of VEGF in the endothelial cells with US alone, after intravenous injection in short-term in vivo experiments.