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Figure 2 Four left coronary artery cineangiographic frames in right anterior oblique view from a single transplant patient are displayed. As compared with baseline (top left), marked epicardial vasodilation was observed at the peak of the highest bradykinin infusion dose (BK, 250 ng/min) (top right) as well as 3 min after a 1-mg intracoronary bolus of linsidomine (Sin-1) (bottom right). On the contrary, marked epicardial vasoconstriction occurred at the peak of the highest acetylcholine infusion dose (ACh, 10-6 M) (bottom left). The simultaneous recording of coronary blood flow velocity with the corresponding value of the average peak velocity (APV) is shown under each angiographic frame.