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Figure 1 Plots show changes in coronary epicardial diameter, average peak velocity (APV) and calculated coronary blood flow, all expressed as the percent of baseline (mean ± SD) in response to increasing doses of bradykinin and acetylcholine, and to 1mg of linsidomine (Sin-1). BK 1, 2 and 3: bradykinin in doses of 50, 150 and 250 ng/min. ACh 1, 2 and 3: acetylcholine at estimated coronary blood concentrations of 10^-8, 10^-7 and 10^-6 M. p < 0.0001 transplant patients versus control subjects.