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Figure 8 Myocyte contractility. The cells were incubated with 10 ng/ml IL-1ß (IL) in the presence or absence of 10–7 mol/liter KT5823, 5 x 10–4 mol/liter aminoguanidine (AG), and 3 mmol/liter NG-monomethyl-L-arginine (L-NMMA), or 10–3 mol/liter sodium nitroprusside (SNP) for 48 h, and cell shortening was measured as described in Methods. 
p < 0.0001 vs. control (n = 10).