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Figure 4 Impaired LV relaxation in HAPE-S subjects during exercise and prolonged hypoxia assessed from mitral inflow velocities. Both exercise and prolonged hypoxia decreased E/A ratios to levels < 1.0 in six of nine patients susceptible to HAPE but in only one control patient; *p = 0.01 at peak exercise, and at **45, ***90 and ****240 min of hypoxia.