Please click here to obtain permission to reproduce this image.

Click on image to view larger version.



Figure 2 Left, Relaxation curves to BNP in the presence (open circles) and absence (open triangles) of endothelium in preconstricted aortic rings from normal rabbits. Right, Relaxation curves to BNP in the presence of endothelium in preconstricted aortic rings from normal rabbits (open circles), atherosclerotic rabbits (open triangles) and atherosclerotic rabbits treated for eight weeks with the orally active NEP inhibitor (NEPI), Candoxatril (UK 79300) (open diamonds). *p < 0.05 vs. normal. {dagger}p < 0.05 vs. atherosclerosis.