Click on image to view larger version.

Figure 4 Transgenic mice with cardiac-specific overexpression of TNF alpha (TNF1.6) develop dilated cardiomyopathy. Representative magnetic resonance image (MRI, coronal view) from 24 week-old wild type (A) and TNF1.6 transgenic mice (B) at equivalent stage of cardiac cycle. (C) Transgenic animals demonstrate significant cardiac hypertrophy with chamber dilation and decreased ejection fraction as determined from MRI data (short-axis images). Adapted after Kubota et al. (50) with author’s permission. BW = body weight; EDV = end-diastolic volume; ESV = end-systolic volume; HW = heart weight. Open square = wild type; solid square = TNF1.6. *p < 0.05.