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Figure 3 (A and B) Bar graphs demonstrating the effects on histomorphometric parameters. In the first group of rats, the injured arteries on one side were treated with the NO donor-polymer mixture (injury + polymer + spermine/NO) and a mixture of spermine, the carrier vehicle for the NO donor, and the polymer was applied to the contralateral injured artery (injury + polymer + spermine). In the second group, the artery on one side was injured without any treatment (injury, no treatment) while the other artery was left uninjured without any treatment (no injury, no treatment). The third group had the polymer alone applied around the injured artery on one side (injury + polymer) while the contralateral uninjured artery was treated with the NO donor/polymer mixture (no injury + polymer + spermine/NO). Data are mean ± SEM: n = number of animals. P values are based on analysis of variance with Tukey’s multiple-comparison test except for A where: * is p < 0.05 vs. injury + polymer + spermine based on planned single-pair comparison. NO = nitric oxide. Open box = no injury, no treatment (n = 8); solid box = injury, no treatment (n = 8); gray box = injury plus polymer (n = 6); slanted line box = injury plus polymer plus spermine (n = 14); dotted box = injury plus polymer plus spermine/NO (n = 14).