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Figure 2 Plasma norepinephrine concentrations versus time as normalized to initial baseline for each patient (value/baseline). Baseline values (mean ± SE) for patients who continued within assigned group from baseline to Study Day 3 were: 485 pg/ml ± 54 (n = 18), 464 pg/ml ± 52 (n = 21), 441 pg/ml ± 31 (n = 27) and 387 pg/ml ± 39 (n = 19) for placebo, 0.2 mg, 0.4 mg and 0.6 mg groups, respectively. Zero hours denote predose values for each study day. Eight hour linearized dose-effect trend on Study Day 2 and 3, p = 0.03 and 0.0006, respectively.