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Figure 1 Bar graph showing FMD values of subjects receiving placebo and of subjects receiving vitamin E (600 IU/day) at baseline, after therapy for four weeks and after heavy smoking at the end of the treatment period. Time factor p value = 0.0065. Group factor p value = 0.5834. Interaction of the time factor and the grouping factor: p = 0.0318. FMD = flow-mediated vasodilation. Open square = placebo; closed square = Vitamin E.