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Figure 2 Left, Bar graph depicting the mean (±SEM) LV end-diastolic volume (EDV) in untreated control dogs (CON) and in dogs treated with bosentan (BOS). Right, Bar graph depicting the mean (±SEM) LV end-systolic volume (ESV) in untreated control dogs and in dogs treated with bosentan. Solid bars indicate values obtained before initiating treatment and hatched bars to values obtained after three months of follow-up or active therapy. Probability values are based on intragroup pretreatment to post-treatment comparisons.