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Figure 1 Summary of the experimental protocol. The horizontal line denotes the time in weeks after surgery. At time = 0, after BS measurements, surgery was performed. Function was followed on a weekly basis. At sacrifice (8 or 12 weeks) tissue samples were taken for histology, beta-adrenergic receptor study, determination of the tissue high energy phosphate content and determination of regional perfusion. BS = baseline, RF = resting flow, CR = coronary reserve, angio = coronary angiography, Dob echo = dobutamine echocardiography, WT = wall thickening measurement using weekly two-dimensional echocardiography.