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Figure 2 Diastolic pressure–volume relation. The LV diastolic pressure was measured 1 to 2 min after each increment of balloon volume. To achieve comparable loading conditions (balloon volumes) in hearts of different sizes, the LV diastolic pressure was plotted versus vol/vol_max. The diabetic pressure–volume relation was shifted to the left, with a significant change in the shape of the curve, indicating increased chamber stiffness. Line with triangles = diabetic animals; line with squares = control animals.