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Figure 1 Plasma levels of IL-6 bioactivity in CHF patients during therapy with low dose (5 mg/daily) and high dose (40 mg/daily) of enalapril at baseline and at end of study. The upper panel (A) shows the absolute concentrations of IL-6 bioactivity during therapy. ***p < 0.001 versus baseline. The lower panel (B) shows the changes in IL-6 bioactivity during therapy (concentration at the end of study—baseline levels). ^#p < 0.001 versus low-dose group. Data in box plots are given as medians, 25th–75th percentiles and ranges.