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Figure 4 Comparison of treatment effects in HCM patients with or without Noonan’s syndrome. Kaplan-Meier analysis of total survival from diagnosis. (A) Noonan patients with conventional management (n = 17; filled squares) compared with Noonan patients from the total HDßB group (n = 8; filled triangles); log-rank p = 0.03. (B) Non-Noonan HCM patients with conventional management (n = 21; open squares) compared with non-Noonan HCM patients from the total HDßB group (n = 18; open triangles); log-rank p = 0.02. Two patients in the conventional management group with some dysmorphic features suggesting Noonan’s syndrome but of average or above average height, one survivor and one nonsurvivor, could not retrospectively be assigned as either Noonan or non-Noonan and were omitted.