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Figure 7 Immunohistochemical detection of the protease CASP-3 in atrial myocardium. (A) Control adult atrium shows weak, diffuse, fine-granular CASP-3 immunoreactions in most myocytes. Note, that only singular fibers showed more intense CASP-3 immunoreactivity (arrow). (B to D) A number of myocytes from dilated and fibrillating atria heavily loaded with coarse-grained CASP-3 deposits (B, arrows). Note that nuclei of the most affected cells demonstrate hyperchromasia (C and D). Bar = 20 µm.