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Figure 2 Representative photomicrograph of in situ hybridization with digoxigenin-labeled TN-C cRNA probe. Immunostaining of the serial section with anti-TN-C antibodies and antisense probe shows that the distribution of TN-C protein (A) correlates with the mRNA (B). Tenascin-C protein (red) and mRNA (dark blue) was detected predominantly in the adventitia (a) and media (m). The neointima (n) was uniformly negative. Magnification: 30x, reduced by 59%.