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Figure 1 Development of myocardial hypertrophy and heart failure after aortic banding. Organ wet weights are shown relative to body weight (BW). (A) Progressive left ventricular (LV) hypertrophy occurs early after aortic banding (closed squares) as compared with sham-operated rats (open squares). (B) Right ventricular (RV) weight increases in animals with banded aorta as left heart failure develops. (C) Twenty-eight days after aortic banding, lung wet weight is increased significantly, indicating congestive heart failure (CHF). Mean ± SEM. *p 0.05; **p 0.0005 (two-tailed t test).