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Figure 4 CD18 expression on circulating neutrophils at 30 min after reperfusion was correlated with the size of the area at risk in the control group (open circles, y = 58.8 + 1.6x, r = 0.83) but not in the group receiving PB1.3 (closed circles, y = 86.9 + 0.3x, r = 0.18). This suggests that the amount of neutrophil activation is dependent on the amount of ischemic–reperfused myocardium and that this activation can be prevented by PB1.3. LV = left ventricle.