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Figure 1 Diagrammatic representation of the infusion protocol for intra-iliac study. After randomization, BK or adenosine was infused at increasing doses for periods of 2 min each. At the onset of pain, either BK or adenosine infusion was continued to complete the infusion protocol and was then stopped. Ten minutes after the disappearance of BK or adenosine-induced pain, the cross-over infusion with adenosine or BK was carried out. At the end of the first phase of the infusion protocol, acetylsalicylate was infused intravenously. Thirty minutes after the end of acetylsalicylate infusion a second randomization was performed, and the same infusion protocol with BK or adenosine was repeated.