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Figure 2 Rate-pressure product (RPP) and mean pulmonary artery pressure (mPAP) at rest (R), after intracoronary administration of phentolamine (Drug), during two levels of supine bicycle exercise (Ex1; Ex2), and after sublingual nitroglycerin administration (NTG). Note the significant rise of both parameters during exercise. However, patients on chronic beta-blockade reached a lower rate-pressure product than did the two other groups. Open circles = alpha-blockers; solid circles = alpha- plus beta-blockers; solid triangles = control group. NTG = nitroglycerin. *p < 0.05 versus alpha- plus beta-blockers.