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Figure 2 Typical histopathologic changes found seven days after EMC virus inoculation. A and B: Heart from a control mouse. C and D: Heart from a mouse treated with pimobendan 1 mg/kg. Extensive myocardial necrosis and cellular infiltration are found in the control preparation. In the mouse treated with pimobendan, less myocardial cellular infiltration exists despite an equivalent amount of myocardial necrosis. Hematoxylin and eosin stain—original magnification: A and C, x 40, reduced by 65%; B and D, x 200, reduced by 65%.