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Figure 4 Schematic of intramyocardial pressure (IMP) in the septum and left anterior descending artery (LAD) flow in dogs, showing controls and animals with pacing-induced left bundle branch block (LBBB). In the latter group the peak pressure moves from systole to early diastole, while the maximum peak diastolic flow occurs later and the acceleration of flow is lower than in the control group. Ts = systolic flow; Td = diastolic flow. From Ono S, et al: Circulation 1992;85:1125–31 (Reproduced with permission).