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Figure 1 Sequential changes in systemic vascular resistance (SVR) in response to endothelin-1 (ET-1) and endothelin-3 (ET-3) infusion. Compared with baseline measurements, the rise in SVR was significant at a 15 pmol/min dose of ET-1 and ET-3 respectively, *p < 0.01. Repeated measures analysis of variance failed to demonstrate differences between ET-1 and ET-3 or between 5 and 15 min of infusion at each dose.