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Figure 5 Bar graph demonstrating the effect of endotoxin treatment (Endo, 1 µg/ml, 6 and 12 h) of human ventricular myocardial preparations in the absence or presence of L-NMMA (100 µmol/liter) on myocardial cGMP content. Acute treatment of atrial trabecula with sodium nitroprusside (SNP, 100 µmol/liter) was performed as a control. Six hours of incubation: n = 6 per condition; 12 h of incubation: n = 10 per condition, atrial preparations: n = 10 per condition. Ordinate: cGMP concentration in fmol/mg wet weight. Data are given as mean ± SEM.