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Figure 5 Representative left atrial pressure–area loops, at baseline and immediately after pacing-induced ischemia from a patient with left anterior descending (LAD) coronary artery disease (A) and a patient with left circumflex (LCx) disease (B). An upward shift of the left atrial pressure–area loop was observed in the patient with LAD, whereas an upward and rightward shift of the left atrial pressure–area loop was observed in the patient with LCx. Furthermore, the area of the pressure–area A loop was significantly increased in the patient with LAD, whereas it decreased in the patient with LCx.