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Figure 4 Representative left ventricular pressure–area loops, at baseline and immediately after pacing-induced ischemia from a patient with left anterior descending (LAD) coronary artery disease (A) and a patient with left circumflex (LCx) disease (B). An upward and rightward shift of the diastolic portion of the left ventricular pressure–area loop was observed as peak systolic pressure declined in both patients.