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Figure 1 Cardiac (A) and pulmonary (B) ET-1 levels in Bio 14.6 Syrian cardiomyopathic hamsters (Bio-CTL) compared with F1B controls (F1B-CTL). Cardiac and pulmonary ET-1 levels were measured by a specific sandwich EIA as described in Materials and Methods. Values are mean ± SEM. (A) #p < 0.0001 vs. age-matched F1B-CTL, 5-week old Bio and 20-week old Bio-CTL. *p < 0.0005 vs. age-matched F1B-CTL. (B) **p < 0.005 vs. age-matched F1B-CTL, 5-week old Bio-CTL and 20-week old Bio-CTL. Open squares = F1B; solid squares = Bio.