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Figure 2 Plasma endothelin-1 (ET-1) spillover in the leg in age-matched normal subjects and in patients with congestive heart failure. Plasma ET-1 spillover in the leg = ET-1 in femoral vein – ET-1 in femoral artery. *p < 0.0001 vs. the value of NYHA class II. #p < 0.0001 vs. the value of NYHA class III with ANOVA by the Scheffé F test.