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Figure 1 Plasma levels of endothelin-1 (ET-1) in age-matched normal subjects and in patients with congestive heart failure. FA = femoral artery; FV = femoral vein. Closed columns represent the ET-1 level in FA and open columns represent the ET-1 level in FV. *p < 0.01, **p < 0.001 vs. the value of the ET-1 level in FA. #p < 0.05 vs. the value of the ET-1 level of NYHA functional class II patients. ##p < 0.0001 vs. the value of the ET-1 level of NYHA functional class II or class III patients with ANOVA by the Scheffé F test.