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Figure 2 The effect of addition of fibrinogen to blood on ADP-induced (1.5 µmol/liter) expression of P-selectin. Values are expression of P-selectin expressed as a percentage of control values and are means ± SEM determined in blood samples from 19 subjects for samples with addition of 500 mg/dl, 12 subjects for samples with addition of 50 mg/dl and 300 mg/dl, and 10 subjects for samples with addition of 100 mg/dl and 200 mg/dl. Results with the addition of each concentration of fibrinogen greater than 50 mg/dl showed significant increases (p < 0.001) compared with control.