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Figure 1 The effect of addition of fibrinogen to blood on ADP-induced expression of P-selectin. Blood was anticoagulated with CTI (32 µg/ml). Degranulation of -granules was determined with flow cytometry and based on detection of surface expression of P-selectin. Values are means ± SEM determined in blood samples from 10 subjects. A significant (p < 0.001) interaction between fibrinogen and ADP was observed. The addition of fibrinogen (100 mg/dl) significantly increased P-selectin expression in response to 1.5 µmol/liter ADP.