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Figure 7 Time-dependent changes in contractile state in a pair of papillary muscles from a PAB cat. Upper Panel: Active force. Lower Panel: Shortening velocity. Papillary muscle 1 (open triangles) was exposed to colchicine at 210 min, 90 min after it had reached mechanical equilibrium. Papillary muscle 2 (closed triangles) was not exposed to colchicine.