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Figure 2 Association between risk factors and adverse events using progressively more specific case definitions. Multivariable odds ratios and 95% confidence intervals (bars) are plotted on a logarithmic scale for risk factors that did not show a significant association with the outcome when using the primary definition of adverse events. All odds ratios are adjusted for variables stated in footnote to Table 2, except for the odds ratios for protamine allergy, which are unadjusted. The odds ratios for protamine allergy for events defined as those occurring within 10 min of protamine in the absence of other causes of hemodynamic compromise are undefinable. The odds ratios for central venous pressure are for each 5-mm increase, and the odds ratios for ejection fraction are for each 10 percentage point increase. CVP = central venous pressure; EF = ejection fraction. Symbols as in Figure 1.