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Figure 1 The percent change in mean arterial pressure following infusion of 10 µg of endothelin-1 (ET-1). Administration of 12.5 mg/kg b.i.d. of the ET_A receptor antagonist BMS-193884 reduced the ET-1 pressor response by approximately 50%. Administration of the ET_A receptor antagonist at 50 mg/kg b.i.d. virtually eliminated the ET-1 pressor response. These two doses of the ET_A receptor antagonist were then used to study the effects of ET_A receptor blockade with the development of pacing-induced CHF.