Click on image to view larger version.

Figure 3 Endothelium-independent relaxation. (A) Dose–response curves of rat aortas exposed to nitroglycerin. The dose–response curves of the in-utero SHS exposed rats are all shifted to the right of the control and neonatal SHS groups. (B) Values of EC50 for nitroglycerin in the four groups of rats. In-utero tobacco smoke exposure increased the EC50 to nitroglycerin, indicating less sensitivity to endothelium-independent relaxation. Abbreviations as in Figure 1.