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Figure 2 Endothelium-dependent relaxation. (A) Dose–response curves of rat aortas exposed to increasing concentration of acetylcholine. In-utero SHS exposure reduced maximal relaxation. (B) Dose–response curves of rat aortas exposed to increasing concentration of the calcium ionophore A23187. In-utero SHS tended to shift the EC50 of the response to the right, indicating reduced sensitivity.