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Figure 1 (A) Dose–response curves of rat aortas exposed to Phe. The dose–response curves of the three groups of SHS-exposed rats are all shifted to the left of that of the control group, indicating greater sensitivity to adrenoceptor-mediated contraction. (B) EC50 values for Phe in the four groups of rats. Both in-utero and neonatal tobacco smoke exposure reduce the EC50 to Phe. SHS_U = in-utero secondhand smoke exposure; SHS_N = neonatal secondhand smoke exposure; SHS_UN = in-utero and neonatal secondhand smoke exposure; Control = no secondhand smoke exposure.