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Figure 3 Effect of 8 µg/kg clonidine infused over 1 h before peritoneal insufflation on endocrine changes induced by carbon dioxide PNO (study 2). Vasopressin, epinephrine, norepinephrine and cortisol were measured at the same time points as in Figure 2. Results are mean ± SEM. *p < 0.05 compared with placebo.