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Figure 2 Example of INVEST study drug titration screen. The calcium antagonist care strategy titration screen is shown with the protocol-recommended dose of verapamil SR at randomization. The physician has the option of modifying the dose according to those shown. Once verified, the physician clicks the submit icon at the bottom left, and the patient’s instructions as they will appear on the label are printed in the box. An electronic signal is sent to the database core to record the drug dose and strategy assignment and also to the mail order pharmacy to initiate distribution of study drug to the patient. A similar titration screen appears for the noncalcium antagonist strategy drugs (not shown).