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Figure 1 EB can be administered both intravenously and intracoronarily. Intravenous administration results in the spontaneous binding of EB to albumin, and subjection of the arterial wall to the 70-kD large complex. Intracoronary administration after a saline flush to remove serum proteins results in subjection of the arterial wall to the smaller 1-kD molecule. Blue staining of the arterial wall indicates a breach in the luminal barrier.