Click on image to view larger version.

Figure 5 The effects of dobutamine on position and slope of the ESPVR, dP/dt_MAX – V_ED and PRSW relations, in control (open bars) and with stenosis (shaded bars). The position of the ESPVR was characterized by calculating the end-systolic volume intercept at a fixed systolic pressure, the position of the dP/dt_MAX – V_ED and PRSW relations by calculating the intercept at a fixed end-diastolic volume (see text for details). A and B show, respectively, the position (V_ES^IND) and the slope (E_ES) of the ESPVR. C and D show the position (dP/dt_MAX^IND) and the slope of the dP/dt_MAX – V_ED relation. E and F show the position (SW^IND) and the slope of the PRSW relation. Statistical significance vs. baseline (dobutamine = 0) within each group (control or stenosis) is indicated by: # = p < 0.05; ## = p < 0.01. Significant differences between control and stenosis at a each dobutamine level are indicated by: * = p < 0.05; ** = p < 0.01. For details see text and Table 1.