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Figure 4 (A) Effects of denopamine and metoprolol on survival of mice to day 14 after EMCV inoculation. Denopamine significantly improved the survival; the effect was significantly blocked by metoprolol at a concentration of 84 µmol/kg. = control group (n = 25); = denopamine, 14 µmol/kg + metoprolol, 84 µmol/kg treatment group (n = 20); = denopamine, 14 µmol/kg + metoprolol, 42 µmol/kg treatment group (n = 10); = denopamine alone, 14 µmol/kg treatment group (n = 25). *p < 0.05 versus control, or versus denopamine, 14 µmol/kg + metoprolol, 84 µmol/kg treatment group. (B) Effect of denopamine and metoprolol on TNF- levels in the heart on day 6. TNF- in the hearts of mice treated with denopamine was significantly lower than in those of control animals. The effect of denopamine was significantly blocked by metoprolol at a concentration of 84 µmol/kg. Values are means ± SE. N = 5 in each group. Deno = denopamine, 14 µmol/kg; low Meto = metoprolol, 42 µmol/kg; high Meto = metoprolol, 84 µmol/kg. *p < 0.05 versus control or 14 µmol/kg denopamine with 84 µmol/kg metoprolol treatment group.