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Figure 1 Apical four-chamber views (end-diastole on left, end-systole on right) from a single patient. Top, Before contrast, there is poor LV endocardial border definition. Middle, After injection of 0.22 mg/kg of ALBUNEX, there is minimal improvement in LV endocardial border delineation and faint LV chamber opacification in diastole. In systole, there is almost no contrast effect. Bottom, After injection of 0.5 mL of OPTISON, there is 100% LV chamber opacification and almost complete endocardial border delineation in both diastole and systole.