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Figure 7 A) SERCA2a normalized to calsequestrin protein levels revealed that the decrease in SERCA2a protein did not reflect a general loss of myocardial Ca2+ handling proteins with age (*p < 0.05 vs. junior age group), and B) SERCA2a normalized to monomeric phospholamban protein levels as an assessment of SERCA2a activity revealed that SERCA2a activity was decreased with age (*p < 0.05 vs. junior age group).