Although this is the first study to primarily focus on the assessment of mortality in patients with CAD based on combined assessment of BMI and central obesity, secondary analyses from 3 previous studies ((8),(11),17) also assessed the prognosis associated with body adiposity patterns in CAD patients, yielding preliminary results. However, the methodologies of these studies were significantly different from our study. In a substudy of patients with acute coronary syndromes from the MERLIN–TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in NSTE-ACS–Thrombolysis In Myocardial Infarction 36) trial (17), only WC was used, and underweight patients were grouped together with normal BMI patients, potentially increasing the mortality of the reference group. In that study, normal weight central obesity showed a trend toward an association with cardiovascular events after adjustment for confounders, but it was not statistically significant. In a study of Korean patients with myocardial infarction (11), normal weight central obesity was not significantly associated with increased mortality using WHR as the measure of central obesity. In addition, in a study of post-menopausal women with CAD (8), normal weight central obesity (defined by WC) was associated with increased mortality after adjustment for age only. Furthermore, in the INTERHEART study, a multinational case-control study of risk factors for first myocardial infarction (18), WC and WHR were also found to be predictors of first myocardial infarction even in normal BMI ranges. However, INTERHEART was not designed to assess risk among those with established CAD, and mortality data were not available. In contrast, Lavie et al. (19) showed that CAD patients with low body fat percentage had higher 3-year mortality than those with high body fat percentage, and in a separate study, also showed that CAD patients with normal BMI and high body fat, and with high BMI and low body fat did not differ with respect to survival (20). These results contrast with our findings, probably because body fat percentage was measured by a simplified method (sum of skinfolds), which assessed subcutaneous fat but not visceral fat, and like BMI, it is also related to total body fat but gives no insight into fat distribution. In addition, contrasting results were also found in a large study of patients with heart failure with reduced ejection fraction (21), where men (but not women) with high WC had lower event-free survival than men with normal WC. However, due to the composite endpoint of the study, we could not directly infer the association of WC with mortality in that cohort.