To examine renal nerve injury following RD, nine obese, hypertensive dogs underwent bilateral RD using the St. Jude Medical EnligHTN™ renal denervation system and eight weeks of hemodynamic monitoring. At the end of the eight-week period, both left and right renal arteries were collected from the aorta to the kidneys. The renal arteries were cut into equal sections, fixed, and embedded in paraffin. Multiple five-micron sections were taken from the bifurcation, main renal artery, and the ostium and stained with hematoxylin-eosin. Sections were examined for the total number of nerves, number of injured nerves, and the distance measured from nerves to the renal artery lumen.