Jaarsma and colleagues performed a meta-analysis to determine the diagnostic accuracy of single-photon emission computed tomography (SPECT), cardiac magnetic resonance (CMR), and positron emission tomography (PET) perfusion imaging. A total of 166 articles compared the diagnostic performance for detecting a (≥50% diameter stenosis) on coronary angiography. Patient-based analysis demonstrated similar sensitivities for SPECT, CMR, and PET with specificities of 61%, 76%, and 81%, respectively. The diagnostic odds ratio were 15.3, 26.4, and 36.5, respectively. In summary, all 3 modalities have high sensitivity, but PET has the highest diagnostic performance. The authors conclude that referring physicians should consider these findings in the context of local expertise and infrastructure.