Two of the independent factors predicting AF recurrence after ablation were C-reactive protein and white blood cell count. Cause and effect with regard to C-reactive protein has been unclear, with 1 study showing that C-reactive protein levels decrease after successful ablation, implying that inflammation is a result of the arrhythmia. The present study (1), however, found that pre-ablation markers of inflammation predicted recurrence, suggesting cause not only for AF but for ablation failure. This finding highlights a conundrum with AF ablation. The more we ablate, the more likely we are to eliminate AF triggers and modify substrate, but the associated inflammatory response may be arrhythmogenic, at least in the short term.