(Table 2) summarizes the genotype counts stratified by study, case control status, and race/ethnic group as well as the adjusted OR, 95% CI, and p values for the association between KIF6 rs20455 SNP and CAD. Crude ORs were not materially different from their respective ORs adjusted for age and sex. Therefore, only ORs adjusted for age and sex are presented. Among Europeans, only one out of the 19 studies (deCODE) demonstrated a nominally significant association between the KIF6 polymorphism and CAD but in the opposite direction of the published literature (the 719Arg allele inversely associated with risk: log additive OR of 0.93, 95% CI: 0.88 to 0.99, log dominant OR of 0.91, 95% CI: 0.85 to 0.99). The meta-analysis produced a point estimate of the log additive OR near unity with very tight confidence intervals (log additive OR of 0.98, 95% CI: 0.95 to 1.02, log dominant OR of 0.97, 95% CI: 0.93 to 1.01). We also found no significant association between the KIF6 rs20455 SNP and CAD among South Asian participants in the INTERHEART study (log additive OR of 1.02, 95% CI: 0.91 to 1.14, log dominant OR of 1.04, 95% CI: 0.87 to 1.24), African American participants in the ADVANCE, CATHGEN, and GeneSTAR studies (fixed-effects meta-analysis log additive OR of 0.91, 95% CI: 0.73 to 1.13, log dominant OR of 0.81, 95% CI: 0.42 to 1.55), and a smaller number of Hispanic, East Asian, and admixed individuals participating in the ADVANCE study (see Table 2 for details).